Mice given non-caloric sweeteners developed glucose intolerance more quickly than those given sucrose or glucose. In these animals the artificial sweeteners quickly altered the mouse microbiome in favor of pathways that enhance absorption of calorie rich glucose and short-chain fatty acids. Authors suggest this may help explain the diabetes epidemic, although this needs to be reproduced in humans.
PositiveTip: Emphasizing healthy food choices, cutting back on "junk" food, and physical activity is better than depending on non-caloric sweeteners to control weight.