Risk of hip fractures increased by 35% in postmenopausal women who had taken proton-pump inhibitors (PPIs) regularly for two years or more. This finding comes from the Nurse’s Health Study of almost 80,000 women with over 600,000 per years of follow-up. Longer use resulted in even higher risk. This risk seemed to be limited to past and current smokers, and remained after adjustments for body weight, hormone replacement therapy and calcium supplements. The risk dropped to insignificant two years after stopping PPI use.
PositiveTip: For good bone health, avoid smoking and only take PPIs if necessary.