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A "Longevity Gene" May Protect Against Cognitive Decline

Long-life may indeed be in the genes

The genetics of late-life dementia, although complex, are getting a lot of attention these days. The gene for chlolesteryl ester transfer protein (CETP) codes for a specific amino acid within the human genome. A majority of those who live beyond 100 have valine at codon 405 and lower cardiovascular risk. A prospective study of 523 individuals over 70 has revealed this polymorphism of valine to isoleucine may also protect from dementia. Much more work remains to be accomplished before we can be certain there is a Methuselah genotype.